'pioneers'
[pioneer.n.01] as in: someone who helps to open up a new line of research or technology or art


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'pioneers'
[pioneer.n.02] as in: one the first colonists or settlers in a new territory


Examples:
they went west as pioneers with only the possessions they could carry with them


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'pioneers'
[pioneer.v.01] as in: open up an area or prepare a way


Examples:
She pioneered a graduate program for women students



'pioneers'
[initiate.v.02] as in: take the lead or initiative in; participate in the development of


Examples:
This South African surgeon pioneered heart transplants



'pioneers'
[pioneer.v.03] as in: open up and explore a new area


Examples:
pioneer space


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